是的，只需添加新绑定：

bindings:
        input:
          destination: topic1
          content-type: application/*+avro
        inputStream1:
          destination: topic_input_1
        inputStream2:
          destination: topic_input_2

        output:
          destination: topic2
          content-type: application/*+avro

        output2:
          destination: output_topic_2

并提供enablebinding和其他附加注解，如streamlistener：

@EnableBinding(MultipleDesBinding.class)
    public class YourApplication {

        @StreamListener
        @SendTo("output")
        public KStream<String, String> topology1(@Input("inputStream") KStream<String, String> inputKStream,
                                                 @Input("inputStream1") KStream<String, String> inputStream1KStream) {

        }

        @StreamListener
        @SendTo("output2")
        public KStream<String, Long> topology2(@Input("inputStream2") KStream<String, String> inputStream2KStream) {

        }
    }

    interface MultipleDesBinding {

        @Input("input")
        KStream<?, ?> input();

        @Input("inputStream1")
        KStream<?, ?> inputStream1();

        @Input("inputStream2")
        KStream<?, ?> inputStream2();

        @Output("output")
        KStream<?, ?> output();

        @Output("output2")
        KStream<?, ?> output2();

    }

您可以在文档：命令式编程模型中查看详细信息。