请尝试：

import re

pat = re.compile(r'"([^"]*)"(.*\t)(.*)')

with open("your_file.txt", "r") as f_in:
    for line in f_in:
        print(pat.sub(r'"\3"\2\1', line.rstrip()))

印刷品：

This "are" a person     is
She was not "right"     here
"a" pencil is not sharpened     The

你真的不需要 re 为这样的小事。
假设您要重写该文件：

with open('foo.txt', 'r+') as txt:
    lines = txt.readlines()
    for k, line in enumerate(lines):
        words = line.split()
        for i, word in enumerate(words[:-1]):
            if word[0] == '"' and word[-1] == '"':
                words[i] = f'"{words[-1]}"'
                words[-1] = word[1:-1]
                break
        lines[k] = ' '.join(words[:-1]) + f'\t{words[-1]}'
    txt.seek(0)
    print(*lines, sep='\n', file=txt)
    txt.truncate()

这就是我的解决方案：
正则表达式= r

import re
file1 = open('test.txt', 'r')
count = 0

while True:

    # Get next line from file
    line = file1.readline()

    # if line is empty
    # end of file is reached
    if not line:
        break
    
    get_tab = line.strip().split('\t')[1]
    regex = r'\"[\s\S]*\"'
    print("original: {} mod ----> {}".format(line.strip(), re.sub(regex, get_tab, line.strip().split('\t')[0])))

我猜这也是解决它的一个办法：
输入readme.txt内容：

This "is" a person  are
She was not "here"  right
"The" pencil is not sharpened   a

编码：

import re
changed_text = []
with open('readme.txt') as x:
    for line in x:
        splitted_text = line.strip().split("\t") # ['This "is" a person', 'are'] etc.
        if re.search(r'\".*\"', line.strip()): # If a quote is found
            qouted_text = re.search(r'\"(.*)\"', line.strip()).group(1)
            changed_text.append(splitted_text[0].replace(qouted_text, splitted_text[1])+"\t"+qouted_text)
with open('readme.txt.modified', 'w') as x:
    for line in changed_text:
        print(line)
        x.write(line+"\n")

结果（自述文件.txt.已修改）：

Thare "are" a person    is
She was not "right" here
"a" pencil is not sharpened The