您可以这样做：

import numpy as np
import re 

with open("FEMMeshGmsh.inp", "r") as file:  
     for line in file.readlines():
       if "+" in line:
           line = line[:-1]
           line_array = line.split(",")
           number_array = line_array[-1].split("E+") 
           line_array[-1] = float(number_array[0]) * 10 ** int(number_array[1])
           a = np.array(line_array)
           print(a)

In [757]: lines="""10,1,0.0000000000000E+00
     ...: 11,1,0.0000000000000E+00
     ...: 26,1,0.0000000000000E+00
     ...: 27,1,0.0000000000000E+00
     ...: 80,1,6.2500000000000E+01""".splitlines()

就在逗号上拆分行;转换为浮点数很容易，因为：

In [758]: lines1 = [l.split(',') for l in lines]

In [759]: lines1
Out[759]: 
[['10', '1', '0.0000000000000E+00'],
 ['11', '1', '0.0000000000000E+00'],
 ['26', '1', '0.0000000000000E+00'],
 ['27', '1', '0.0000000000000E+00'],
 ['80', '1', '6.2500000000000E+01']]

In [760]: arr = np.array(lines1,float)

In [761]: arr
Out[761]: 
array([[10. ,  1. ,  0. ],
       [11. ,  1. ,  0. ],
       [26. ,  1. ,  0. ],
       [27. ,  1. ,  0. ],
       [80. ,  1. , 62.5]])

或者只使用list和float：

In [762]: lines[0].split(',')
Out[762]: ['10', '1', '0.0000000000000E+00']

In [763]: float(lines[0].split(',')[2])
Out[763]: 0.0

In [764]: float(lines[-1].split(',')[2])
Out[764]: 62.5