请尝试以下操作：

import glob
import pandas as pd

# Give the filename you wish to save the file to
filename = 'Your_filename.csv'

# Use this function to search for any files which match your filename
files_present = glob.glob(filename)

# if no matching files, write to csv, if there are matching files, print statement
if not files_present:
    pd.to_csv(filename)
else:
    print 'WARNING: This file already exists!'

我还没有测试过这个，但是它已经从我以前写的一些代码中被提升和编译了。这将简单地阻止文件覆盖其他文件。注意：你将不得不自己修改文件名变量，然后保存文件，或者按照你的建议使用一些日期时间变量。我希望这在某种程度上有所帮助。

根据TaylorDay的建议，我对这个函数做了一些调整。下面的代码会询问你是否要覆盖一个现有的文件。如果不想，你可以键入另一个名称。然后，调用相同的write函数，它会再次检查new_filename是否存在。

from os import path
import pandas as pd
def write_csv_df(path, filename, df):
    # Give the filename you wish to save the file to
    pathfile = os.path.normpath(os.path.join(path,filename))

    # Use this function to search for any files which match your filename
    files_present = os.path.isfile(pathfile) 
    # if no matching files, write to csv, if there are matching files, print statement
    if not files_present:
        df.to_csv(pathfile, sep=';')
    else:
        overwrite = raw_input("WARNING: " + pathfile + " already exists! Do you want to overwrite <y/n>? \n ")
        if overwrite == 'y':
            df.to_csv(pathfile, sep=';')
        elif overwrite == 'n':
            new_filename = raw_input("Type new filename: \n ")
            write_csv_df(path,new_filename,df)
        else:
            print "Not a valid input. Data is NOT saved!\n"

对于3.3以上版本，请使用mode='x'
来自文档：
以独占方式打开创建，如果文件已存在则失败

try:
    df.to_csv('abc.csv', mode='x')
except FileExistsError:
    df.to_csv('unique_name.csv')

# if you already has a file with the name "out"
    # nothing will happen as pass gets excuted
try:
    df.to_csv('out.csv')
except:
    pass