我不建议更改ListViewItem模板，因为您会失去它提供的所有功能（选择外观、检查能力等）。
在第二个代码段中使用Mode=TemplatedParent将不起作用，因为该上下文中的模板化父项是ListViewItemPresenter，而不是ListViewItem（表示者的父项）。
看起来您尝试做的是在选中列表项时在其中显示附加信息。

单选

• • C#类别**

public class NotifyPropertyChangedBase : INotifyPropertyChanged
{
    public event PropertyChangedEventHandler PropertyChanged;

    protected void OnPropertyChanged([CallerMemberName] string propertyName = "")
    {
        PropertyChanged?.Invoke(this, new PropertyChangedEventArgs(propertyName));
    }

    protected bool SetProperty<T>(ref T property, T value, [CallerMemberName] string propertyName = "")
    {
        if (EqualityComparer<T>.Default.Equals(property, value))
        {
            return false;
        }

        property = value;
        OnPropertyChanged(propertyName);
        return true;
    }
}

public class Item : NotifyPropertyChangedBase
{
    private string text;
    public string Text
    {
        get { return text; }
        set { SetProperty(ref text, value); }
    }

    private bool isSelected;
    public bool IsSelected
    {
        get { return isSelected; }
        set { SetProperty(ref isSelected, value); }
    }
}

public class MainPageViewModel : NotifyPropertyChangedBase
{
    public List<Item> Items { get; set; }

    private Item selectedItem;
    public Item SelectedItem
    {
        get { return selectedItem; }
        set
        {
            if (selectedItem != value)
            {
                if (selectedItem != null)
                {
                    selectedItem.IsSelected = false;
                }

                SetProperty(ref selectedItem, value);

                if (selectedItem != null)
                {
                    selectedItem.IsSelected = true;
                }
            }
        }
    }

    public MainPageViewModel()
    {
        Items = new List<Item>()
        {
            new Item() { Text = "Apple" },
            new Item() { Text = "Banana" },
        };
    }
}

• • 主页面. xaml**

<ListView ItemsSource="{Binding Items}" SelectedItem="{Binding SelectedItem, Mode=TwoWay}">
    <ListView.ItemContainerStyle>
        <Style TargetType="ListViewItem">
            <Setter Property="HorizontalContentAlignment" Value="Stretch"/>
        </Style>
    </ListView.ItemContainerStyle>
    <ListView.ItemTemplate>
        <DataTemplate x:DataType="local:Item">
            <Grid>
                <Grid.ColumnDefinitions>
                    <ColumnDefinition/>
                    <ColumnDefinition Width="Auto"/>
                </Grid.ColumnDefinitions>

                <TextBlock Text="{Binding Text}"/>

                <!-- x:Bind doesn't require visibility converter if min SDK is targeting Anniversary update -->
                <TextBlock Text="I'm selected!" Grid.Column="1" Visibility="{x:Bind IsSelected, Mode=OneWay}"/>
            </Grid>
        </DataTemplate>
    </ListView.ItemTemplate>
</ListView>

• • 主页面. xaml. cs**

public sealed partial class MainPage : Page
{
    public MainPage()
    {
        this.InitializeComponent();
        DataContext = new MainPageViewModel();
    }
}

多重选择

与单一选取相同，但有以下变更：

• • 主页视图模型**

public class MainPageViewModel : NotifyPropertyChangedBase
{
    public List<Item> Items { get; set; }

    public MainPageViewModel()
    {
        Items = new List<Item>()
        {
            new Item() { Text = "Apple" },
            new Item() { Text = "Banana" },
        };
    }

    public void SelectionChanged(object sender, SelectionChangedEventArgs e)
    {
        foreach (Item item in e.RemovedItems)
        {
            item.IsSelected = false;
        }

        foreach (Item item in e.AddedItems)
        {
            item.IsSelected = true;
        }
    }
}

• • 主页面. xaml**

<ListView ItemsSource="{Binding Items}" SelectionChanged="{x:Bind ViewModel.SelectionChanged}" SelectionMode="Extended">
    <ListView.ItemContainerStyle>
        <Style TargetType="ListViewItem">
            <Setter Property="HorizontalContentAlignment" Value="Stretch"/>
        </Style>
    </ListView.ItemContainerStyle>
    <ListView.ItemTemplate>
        <DataTemplate x:DataType="local:Item">
            <Grid>
                <Grid.ColumnDefinitions>
                    <ColumnDefinition/>
                    <ColumnDefinition Width="Auto"/>
                </Grid.ColumnDefinitions>

                <TextBlock Text="{Binding Text}"/>
                <TextBlock Text="I'm selected!" Grid.Column="1" Visibility="{x:Bind IsSelected, Mode=OneWay}"/>
            </Grid>
        </DataTemplate>
    </ListView.ItemTemplate>
</ListView>

• • 主页面. xaml. cs**

public sealed partial class MainPage : Page
{
    public MainPage()
    {
        this.InitializeComponent();
        DataContext = new MainPageViewModel();
    }

    public MainPageViewModel ViewModel => (MainPageViewModel)DataContext;
}

若要回答主题中的实际问题：是的，您可以很容易地绑定ListViewItem.IsSelected。请确保您的DataTemplate内容 Package 在ListViewItem中。

<ListView.ItemTemplate>
    <DataTemplate x:DataType="local:MyItemViewModel">
        <ListViewItem IsSelected="{Binding IsSelected, Mode=TwoWay}">
            <Grid>
                // template content
            </Grid>
        </ListViewItem>
    </DataTemplate>
</ListView.ItemTemplate>

请注意，这里有许多关于WPF的问答都说这不起作用。它可以与UWP一起工作（至少在SDK 10.0.19041中）。WPF的回答建议将它绑定到ItemsPanelTemplate或ResourceDictionary中。由于某种原因，这在UWP中不起作用。

我执行了以下操作，效果很好

<ListView.ItemTemplate>
    <DataTemplate x:DataType="local:PersonalProfile">
        <ListViewItem x:Name="root">
             <Grid >
             <!-- .... -->
                 <CheckBox IsChecked="{Binding ElementName=root, Path=IsSelected, Mode=TwoWay, UpdateSourceTrigger=PropertyChanged}"/>
             </Grid>
        </ListViewItem>
    </DataTemplate>
</ListView.ItemTemplate>