您可以使用SetupDi API从Win32启用/禁用设备（因此可以通过P/Invoke从C#启用/禁用），但并非所有设备都可以通过这种方式“禁用”。
您在尝试从Win32禁用触摸板时遇到的问题（或WMI或调用SetupDi*系列函数的任何其他API）是大多数带触摸板的笔记本电脑中的默认鼠标驱动程序（“PS/2兼容鼠标”）不支持使用SetupDi API禁用。我怀疑这可能是因为使用PS/2连接器的实际旧鼠标无法“不要在不冲洗硬件的情况下进行热拆卸。
要验证您是否无法禁用，请进入设备管理器并右键单击鼠标驱动程序。如果您看到禁用选项，您可以使用SetupDi来禁用它。如果没有禁用选项，您就不走运了...欢迎来到IOCTL世界！
如果您看到了禁用选项，那么下面的代码（从我找到的here的VB示例移植到C#）应该可以让您禁用和重新启用设备。
下面是调用该库的代码：

public static void EnableMouse(bool enable)
    {
        // every type of device has a hard-coded GUID, this is the one for mice
        Guid mouseGuid = new Guid("{4d36e96f-e325-11ce-bfc1-08002be10318}");
        
        // get this from the properties dialog box of this device in Device Manager
        string instancePath = @"ACPI\PNP0F03\4&3688D3F&0";
        
        DeviceHelper.SetDeviceEnabled(mouseGuid, instancePath, enable);
    }

这是库本身，改编自here。

using System;
using System.Text;
using System.Collections.Generic;
using DisableDevice;
using System.Runtime.InteropServices;
using System.ComponentModel;
using Microsoft.Win32.SafeHandles;
using System.Security;
using System.Runtime.ConstrainedExecution;
using System.Management;

namespace DisableDevice
{

    [Flags()]
    internal enum SetupDiGetClassDevsFlags
    {
        Default = 1,
        Present = 2,
        AllClasses = 4,
        Profile = 8,
        DeviceInterface = (int)0x10
    }

    internal enum DiFunction
    {
        SelectDevice = 1,
        InstallDevice = 2,
        AssignResources = 3,
        Properties = 4,
        Remove = 5,
        FirstTimeSetup = 6,
        FoundDevice = 7,
        SelectClassDrivers = 8,
        ValidateClassDrivers = 9,
        InstallClassDrivers = (int)0xa,
        CalcDiskSpace = (int)0xb,
        DestroyPrivateData = (int)0xc,
        ValidateDriver = (int)0xd,
        Detect = (int)0xf,
        InstallWizard = (int)0x10,
        DestroyWizardData = (int)0x11,
        PropertyChange = (int)0x12,
        EnableClass = (int)0x13,
        DetectVerify = (int)0x14,
        InstallDeviceFiles = (int)0x15,
        UnRemove = (int)0x16,
        SelectBestCompatDrv = (int)0x17,
        AllowInstall = (int)0x18,
        RegisterDevice = (int)0x19,
        NewDeviceWizardPreSelect = (int)0x1a,
        NewDeviceWizardSelect = (int)0x1b,
        NewDeviceWizardPreAnalyze = (int)0x1c,
        NewDeviceWizardPostAnalyze = (int)0x1d,
        NewDeviceWizardFinishInstall = (int)0x1e,
        Unused1 = (int)0x1f,
        InstallInterfaces = (int)0x20,
        DetectCancel = (int)0x21,
        RegisterCoInstallers = (int)0x22,
        AddPropertyPageAdvanced = (int)0x23,
        AddPropertyPageBasic = (int)0x24,
        Reserved1 = (int)0x25,
        Troubleshooter = (int)0x26,
        PowerMessageWake = (int)0x27,
        AddRemotePropertyPageAdvanced = (int)0x28,
        UpdateDriverUI = (int)0x29,
        Reserved2 = (int)0x30
    }

    internal enum StateChangeAction
    {
        Enable = 1,
        Disable = 2,
        PropChange = 3,
        Start = 4,
        Stop = 5
    }

    [Flags()]
    internal enum Scopes
    {
        Global = 1,
        ConfigSpecific = 2,
        ConfigGeneral = 4
    }

    internal enum SetupApiError
    {
        NoAssociatedClass = unchecked((int)0xe0000200),
        ClassMismatch = unchecked((int)0xe0000201),
        DuplicateFound = unchecked((int)0xe0000202),
        NoDriverSelected = unchecked((int)0xe0000203),
        KeyDoesNotExist = unchecked((int)0xe0000204),
        InvalidDevinstName = unchecked((int)0xe0000205),
        InvalidClass = unchecked((int)0xe0000206),
        DevinstAlreadyExists = unchecked((int)0xe0000207),
        DevinfoNotRegistered = unchecked((int)0xe0000208),
        InvalidRegProperty = unchecked((int)0xe0000209),
        NoInf = unchecked((int)0xe000020a),
        NoSuchHDevinst = unchecked((int)0xe000020b),
        CantLoadClassIcon = unchecked((int)0xe000020c),
        InvalidClassInstaller = unchecked((int)0xe000020d),
        DiDoDefault = unchecked((int)0xe000020e),
        DiNoFileCopy = unchecked((int)0xe000020f),
        InvalidHwProfile = unchecked((int)0xe0000210),
        NoDeviceSelected = unchecked((int)0xe0000211),
        DevinfolistLocked = unchecked((int)0xe0000212),
        DevinfodataLocked = unchecked((int)0xe0000213),
        DiBadPath = unchecked((int)0xe0000214),
        NoClassInstallParams = unchecked((int)0xe0000215),
        FileQueueLocked = unchecked((int)0xe0000216),
        BadServiceInstallSect = unchecked((int)0xe0000217),
        NoClassDriverList = unchecked((int)0xe0000218),
        NoAssociatedService = unchecked((int)0xe0000219),
        NoDefaultDeviceInterface = unchecked((int)0xe000021a),
        DeviceInterfaceActive = unchecked((int)0xe000021b),
        DeviceInterfaceRemoved = unchecked((int)0xe000021c),
        BadInterfaceInstallSect = unchecked((int)0xe000021d),
        NoSuchInterfaceClass = unchecked((int)0xe000021e),
        InvalidReferenceString = unchecked((int)0xe000021f),
        InvalidMachineName = unchecked((int)0xe0000220),
        RemoteCommFailure = unchecked((int)0xe0000221),
        MachineUnavailable = unchecked((int)0xe0000222),
        NoConfigMgrServices = unchecked((int)0xe0000223),
        InvalidPropPageProvider = unchecked((int)0xe0000224),
        NoSuchDeviceInterface = unchecked((int)0xe0000225),
        DiPostProcessingRequired = unchecked((int)0xe0000226),
        InvalidCOInstaller = unchecked((int)0xe0000227),
        NoCompatDrivers = unchecked((int)0xe0000228),
        NoDeviceIcon = unchecked((int)0xe0000229),
        InvalidInfLogConfig = unchecked((int)0xe000022a),
        DiDontInstall = unchecked((int)0xe000022b),
        InvalidFilterDriver = unchecked((int)0xe000022c),
        NonWindowsNTDriver = unchecked((int)0xe000022d),
        NonWindowsDriver = unchecked((int)0xe000022e),
        NoCatalogForOemInf = unchecked((int)0xe000022f),
        DevInstallQueueNonNative = unchecked((int)0xe0000230),
        NotDisableable = unchecked((int)0xe0000231),
        CantRemoveDevinst = unchecked((int)0xe0000232),
        InvalidTarget = unchecked((int)0xe0000233),
        DriverNonNative = unchecked((int)0xe0000234),
        InWow64 = unchecked((int)0xe0000235),
        SetSystemRestorePoint = unchecked((int)0xe0000236),
        IncorrectlyCopiedInf = unchecked((int)0xe0000237),
        SceDisabled = unchecked((int)0xe0000238),
        UnknownException = unchecked((int)0xe0000239),
        PnpRegistryError = unchecked((int)0xe000023a),
        RemoteRequestUnsupported = unchecked((int)0xe000023b),
        NotAnInstalledOemInf = unchecked((int)0xe000023c),
        InfInUseByDevices = unchecked((int)0xe000023d),
        DiFunctionObsolete = unchecked((int)0xe000023e),
        NoAuthenticodeCatalog = unchecked((int)0xe000023f),
        AuthenticodeDisallowed = unchecked((int)0xe0000240),
        AuthenticodeTrustedPublisher = unchecked((int)0xe0000241),
        AuthenticodeTrustNotEstablished = unchecked((int)0xe0000242),
        AuthenticodePublisherNotTrusted = unchecked((int)0xe0000243),
        SignatureOSAttributeMismatch = unchecked((int)0xe0000244),
        OnlyValidateViaAuthenticode = unchecked((int)0xe0000245)
    }

    [StructLayout(LayoutKind.Sequential)]
    internal struct DeviceInfoData
    {
        public int Size;
        public Guid ClassGuid;
        public int DevInst;
        public IntPtr Reserved;
    }

    [StructLayout(LayoutKind.Sequential)]
    internal struct PropertyChangeParameters
    {
        public int Size;
        // part of header. It's flattened out into 1 structure.
        public DiFunction DiFunction;
        public StateChangeAction StateChange;
        public Scopes Scope;
        public int HwProfile;
    }

    internal class NativeMethods
    {

        private const string setupapi = "setupapi.dll";

        private NativeMethods()
        {
        }

        [DllImport(setupapi, CallingConvention = CallingConvention.Winapi, SetLastError = true)]
        [return: MarshalAs(UnmanagedType.Bool)]
        public static extern bool SetupDiCallClassInstaller(DiFunction installFunction, SafeDeviceInfoSetHandle deviceInfoSet, [In()]
ref DeviceInfoData deviceInfoData);

        [DllImport(setupapi, CallingConvention = CallingConvention.Winapi, SetLastError = true)]
        [return: MarshalAs(UnmanagedType.Bool)]
        public static extern bool SetupDiEnumDeviceInfo(SafeDeviceInfoSetHandle deviceInfoSet, int memberIndex, ref DeviceInfoData deviceInfoData);

        [DllImport(setupapi, CallingConvention = CallingConvention.Winapi, CharSet = CharSet.Unicode, SetLastError = true)]
        public static extern SafeDeviceInfoSetHandle SetupDiGetClassDevs([In()]
ref Guid classGuid, [MarshalAs(UnmanagedType.LPWStr)]
string enumerator, IntPtr hwndParent, SetupDiGetClassDevsFlags flags);

        /*
        [DllImport(setupapi, CallingConvention = CallingConvention.Winapi, CharSet = CharSet.Unicode, SetLastError = true)]
        [return: MarshalAs(UnmanagedType.Bool)]
        public static extern bool SetupDiGetDeviceInstanceId(SafeDeviceInfoSetHandle deviceInfoSet, [In()]
ref DeviceInfoData did, [MarshalAs(UnmanagedType.LPTStr)]
StringBuilder deviceInstanceId, int deviceInstanceIdSize, [Out()]
ref int requiredSize);
        */
        [DllImport("setupapi.dll", SetLastError = true, CharSet = CharSet.Auto)]
        [return: MarshalAs(UnmanagedType.Bool)]
        public static extern bool SetupDiGetDeviceInstanceId(
           IntPtr DeviceInfoSet,
           ref DeviceInfoData did,
           [MarshalAs(UnmanagedType.LPTStr)] StringBuilder DeviceInstanceId,
           int DeviceInstanceIdSize,
           out int RequiredSize
        );

        [SuppressUnmanagedCodeSecurity()]
        [ReliabilityContract(Consistency.WillNotCorruptState, Cer.Success)]
        [DllImport(setupapi, CallingConvention = CallingConvention.Winapi, SetLastError = true)]
        [return: MarshalAs(UnmanagedType.Bool)]
        public static extern bool SetupDiDestroyDeviceInfoList(IntPtr deviceInfoSet);

        [DllImport(setupapi, CallingConvention = CallingConvention.Winapi, SetLastError = true)]
        [return: MarshalAs(UnmanagedType.Bool)]
        public static extern bool SetupDiSetClassInstallParams(SafeDeviceInfoSetHandle deviceInfoSet, [In()]
ref DeviceInfoData deviceInfoData, [In()]
ref PropertyChangeParameters classInstallParams, int classInstallParamsSize);

    }

    internal class SafeDeviceInfoSetHandle : SafeHandleZeroOrMinusOneIsInvalid
    {

        public SafeDeviceInfoSetHandle()
            : base(true)
        {
        }

        protected override bool ReleaseHandle()
        {
            return NativeMethods.SetupDiDestroyDeviceInfoList(this.handle);
        }

    }

    public sealed class DeviceHelper
    {

        private DeviceHelper()
        {
        }

        /// <summary>
        /// Enable or disable a device.
        /// </summary>
        /// <param name="classGuid">The class guid of the device. Available in the device manager.</param>
        /// <param name="instanceId">The device instance id of the device. Available in the device manager.</param>
        /// <param name="enable">True to enable, False to disable.</param>
        /// <remarks>Will throw an exception if the device is not Disableable.</remarks>
        public static void SetDeviceEnabled(Guid classGuid, string instanceId, bool enable)
        {
            SafeDeviceInfoSetHandle diSetHandle = null;
            try
            {
                // Get the handle to a device information set for all devices matching classGuid that are present on the 
                // system.
                diSetHandle = NativeMethods.SetupDiGetClassDevs(ref classGuid, null, IntPtr.Zero, SetupDiGetClassDevsFlags.Present);
                // Get the device information data for each matching device.
                DeviceInfoData[] diData = GetDeviceInfoData(diSetHandle);
                // Find the index of our instance. i.e. the touchpad mouse - I have 3 mice attached...
                int index = GetIndexOfInstance(diSetHandle, diData, instanceId);
                // Disable...
                EnableDevice(diSetHandle, diData[index], enable);
            }
            finally
            {
                if (diSetHandle != null)
                {
                    if (diSetHandle.IsClosed == false)
                    {
                        diSetHandle.Close();
                    }
                    diSetHandle.Dispose();
                }
            }
        }

        private static DeviceInfoData[] GetDeviceInfoData(SafeDeviceInfoSetHandle handle)
        {
            List<DeviceInfoData> data = new List<DeviceInfoData>();
            DeviceInfoData did = new DeviceInfoData();
            int didSize = Marshal.SizeOf(did);
            did.Size = didSize;
            int index = 0;
            while (NativeMethods.SetupDiEnumDeviceInfo(handle, index, ref did))
            {
                data.Add(did);
                index += 1;
                did = new DeviceInfoData();
                did.Size = didSize;
            }
            return data.ToArray();
        }

        // Find the index of the particular DeviceInfoData for the instanceId.
        private static int GetIndexOfInstance(SafeDeviceInfoSetHandle handle, DeviceInfoData[] diData, string instanceId)
        {
            const int ERROR_INSUFFICIENT_BUFFER = 122;
            for (int index = 0; index <= diData.Length - 1; index++)
            {
                StringBuilder sb = new StringBuilder(1);
                int requiredSize = 0;
                bool result = NativeMethods.SetupDiGetDeviceInstanceId(handle.DangerousGetHandle(), ref diData[index], sb, sb.Capacity, out requiredSize);
                if (result == false && Marshal.GetLastWin32Error() == ERROR_INSUFFICIENT_BUFFER)
                {
                    sb.Capacity = requiredSize;
                    result = NativeMethods.SetupDiGetDeviceInstanceId(handle.DangerousGetHandle(), ref diData[index], sb, sb.Capacity, out requiredSize);
                }
                if (result == false)
                    throw new Win32Exception();
                if (instanceId.Equals(sb.ToString()))
                {
                    return index;
                }
            }
            // not found
            return -1;
        }

        // enable/disable...
        private static void EnableDevice(SafeDeviceInfoSetHandle handle, DeviceInfoData diData, bool enable)
        {
            PropertyChangeParameters @params = new PropertyChangeParameters();
            // The size is just the size of the header, but we've flattened the structure.
            // The header comprises the first two fields, both integer.
            @params.Size = 8;
            @params.DiFunction = DiFunction.PropertyChange;
            @params.Scope = Scopes.Global;
            if (enable)
            {
                @params.StateChange = StateChangeAction.Enable;
            }
            else
            {
                @params.StateChange = StateChangeAction.Disable;
            }

            bool result = NativeMethods.SetupDiSetClassInstallParams(handle, ref diData, ref @params, Marshal.SizeOf(@params));
            if (result == false) throw new Win32Exception();
            result = NativeMethods.SetupDiCallClassInstaller(DiFunction.PropertyChange, handle, ref diData);
            if (result == false)
            {
                int err = Marshal.GetLastWin32Error();
                if (err == (int)SetupApiError.NotDisableable)
                    throw new ArgumentException("Device can't be disabled (programmatically or in Device Manager).");
                else if (err >= (int)SetupApiError.NoAssociatedClass && err <= (int)SetupApiError.OnlyValidateViaAuthenticode)
                    throw new Win32Exception("SetupAPI error: " + ((SetupApiError)err).ToString());
                else
                    throw new Win32Exception();
            }
        }
    }
}

请注意，当您在int index = GetIndexOfInstance(diSetHandle, diData, instanceId);行上获得Index-Out-Of-Bounds异常时，您可能使用了错误的设备classGuid或错误的instanceId。
另请注意，当您在64位Windows平台上运行此代码时，在生成应用程序时应将目标定位为64位平台。否则，即当应用程序作为32位进程在64位Windows平台上运行时，您将收到SetupAPI错误InWow 64（ERROR_IN_WOW64）。
当目标是64位Windows平台时，您可能还必须对应用程序的其他部分进行更改（例如，在执行指针运算时），以防止溢出。

一种方法可能是使用Windows Management Instrumentation层，在这个层中似乎定义了一些与设备相关的类。

• • 您可以考虑下面提到的Win API****CM_Request_Device_EjectW函数：**CM_Request_Device_Eject函数为安全删除准备本地设备示例。如果设备是可删除的。**CM_Query_And_Remove_SubTreeW函数：**CM_Query_And_Remove_SubTree函数检查是否可以删除设备示例及其子项，如果可以，则将其删除。

同样的情况也可以在这里找到：CM_Request_Device_EjectW和CM_Query_And_Remove_SubTreeW

如果您想 * 切换 * 设备启用状态，可以通过将SetDeviceEnabled替换为以下内容来修改@JustinGrant的惊人解决方案：

public static void ToggleDeviceEnabled(Guid classGuid, string instanceId)
{
    SafeDeviceInfoSetHandle diSetHandle = null;
    try
    {
        (diSetHandle, var did) = GetDeviceInfo(classGuid, instanceId);
        // according to https://stackoverflow.com/a/13105326/308451
        // the answer might lie in CM_Get_DevNode_Status. Let's try.

        int result = NativeMethods.CM_Get_DevNode_Status(out uint devNodeStatus, out uint probNum, did.DevInst);
        // return value meanings are in Cfgmgr32.h., but CR_SUCCESS is one of them
        const int CR_SUCCESS = 0;
        if (result != CR_SUCCESS)
            throw new Win32Exception();

        // devNodeStatus now contains status bit flags: any combination of the DN_- prefixed bit flags defined in Cfg.h.
        // one of the flags is
        const uint DN_STARTED = 0x00000008; // Is currently configured

        bool currentlyEnabled = HasFlag(devNodeStatus, DN_STARTED);
        bool enable = !currentlyEnabled;

        // toggle
        EnableDevice(diSetHandle, did, enable);
    }
    finally
    {
        if (diSetHandle != null)
        {
            if (diSetHandle.IsClosed == false)
            {
                diSetHandle.Close();
            }
            diSetHandle.Dispose();
        }
    }
}

static bool HasFlag(uint flags, uint flag)
{
    return (flags & flag) == flag;
}
private static (SafeDeviceInfoSetHandle, DeviceInfoData) GetDeviceInfo(Guid classGuid, string instanceId)
{
    // Get the handle to a device information set for all devices matching classGuid that are present on the system.
    var diSetHandle = NativeMethods.SetupDiGetClassDevs(ref classGuid, null, IntPtr.Zero, SetupDiGetClassDevsFlags.Present);
    // Get the device information data for each matching device.
    DeviceInfoData[] diData = GetDeviceInfoData(diSetHandle);
    // Find the index of our instance. i.e. the touchpad mouse - I have 3 mice attached...
    int index = GetIndexOfInstance(diSetHandle, diData, instanceId);

    return (diSetHandle, diData[index]);
}
[DllImport("cfgmgr32.dll", SetLastError = true)]
public static extern int CM_Get_DevNode_Status(out uint status, out uint probNum, int devInst, int flags = 0);