这是VS 2005的错误报告：https://connect.microsoft.com/VisualStudio/feedback/ViewFeedback.aspx?FeedbackID=117002&wa=wsignin1.0#
看起来微软并不想纠正这个问题。“按设计”？真是个笑话。

试试这个：

var cols = dcols.ToArray();//dcols is the DataGridViewColumn List wait to add to DataGridView
    if (cols.Last().Frozen)
    {
        _this.RightToLeft = RightToLeft.Yes;
        cols = cols.Reverse().ToArray();
    } 
    _this.Columns.AddRange(cols);
    //Note that DataGridView does not allow freezing on both sides at the same time, or freezing some columns in the middle.

你会遇到一个问题。滚动条将被定位到最右边。然后，你可以尝试下面的代码：

//OnDataBindingComplete
        if (this.Columns.Count > 0)
            this.FirstDisplayedScrollingColumnIndex = this.Columns.Count - 1;