您可以使用\d+/\d+$来匹配两组连续的数字，这两组数字在字符串结尾之前用斜杠分隔。

let s = 'https://test.com/id/3/5000/333';
let res = s.replace(/\d+\/\d+$/, 123 + '/' + 456);
console.log(res);

如果您有queryParams，您可以尝试从原始URL字符串构造一个URL对象并操作pathname。

const randomInt = (limit) => Math.floor(Math.random() * limit);

const originalUrl = 'https://test.com/id/3/5000/333?test=true';
const urlObj = new URL(originalUrl);
const parts = urlObj.pathname.split('/').filter(path => path.length);

// Modify the last and second-to-last path values
parts[parts.length - 1] = randomInt(1000);
parts[parts.length - 2] = randomInt(10000);

// Re-join the parts of the path
urlObj.pathname = parts.join('/');

const modifiedUrl = urlObj.toString();

console.log(modifiedUrl);