几周前我遇到过类似的问题，当我在polyfills中更改一些设置时，我解决了它。

/**
 * This file includes polyfills needed by Angular and is loaded before the app.
 * You can add your own extra polyfills to this file.
 *
 * This file is divided into 2 sections:
 *   1. Browser polyfills. These are applied before loading ZoneJS and are sorted by browsers.
 *   2. Application imports. Files imported after ZoneJS that should be loaded before your main
 *      file.
 *
 * The current setup is for so-called "evergreen" browsers; the last versions of browsers that
 * automatically update themselves. This includes Safari >= 10, Chrome >= 55 (including Opera),
 * Edge >= 13 on the desktop, and iOS 10 and Chrome on mobile.
 *
 * Learn more in https://angular.io/docs/ts/latest/guide/browser-support.html
 */

/***************************************************************************************************
 * BROWSER POLYFILLS
 */

/** IE9, IE10 and IE11 requires all of the following polyfills. **/
// import 'core-js/es6/symbol';
// import 'core-js/es6/object';
// import 'core-js/es6/function';
// import 'core-js/es6/parse-int';
// import 'core-js/es6/parse-float';
// import 'core-js/es6/number';
// import 'core-js/es6/math';
// import 'core-js/es6/string';
// import 'core-js/es6/date';
// import 'core-js/es6/array';
// import 'core-js/es6/regexp';
// import 'core-js/es6/map';
// import 'core-js/es6/weak-map';
// import 'core-js/es6/set';

/** IE10 and IE11 requires the following for NgClass support on SVG elements */
// import 'classlist.js';  // Run `npm install --save classlist.js`.

/** IE10 and IE11 requires the following for the Reflect API. */
// import 'core-js/es6/reflect';

/** Evergreen browsers require these. **/
// Used for reflect-metadata in JIT. If you use AOT (and only Angular decorators), you can remove.
import 'core-js/es7/reflect';

/**
 * Required to support Web Animations `@angular/platform-browser/animations`.
 * Needed for: All but Chrome, Firefox and Opera. http://caniuse.com/#feat=web-animation
 **/
import 'web-animations-js';  // Run `npm install --save web-animations-js`.

/**
 * By default, zone.js will patch all possible macroTask and DomEvents
 * user can disable parts of macroTask/DomEvents patch by setting following flags
 */

 // (window as any).__Zone_disable_requestAnimationFrame = true; // disable patch requestAnimationFrame
 // (window as any).__Zone_disable_on_property = true; // disable patch onProperty such as onclick
 // (window as any).__zone_symbol__BLACK_LISTED_EVENTS = ['scroll', 'mousemove']; // disable patch specified eventNames

 /*
 * in IE/Edge developer tools, the addEventListener will also be wrapped by zone.js
 * with the following flag, it will bypass `zone.js` patch for IE/Edge
 */
// (window as any).__Zone_enable_cross_context_check = true;

/***************************************************************************************************
 * Zone JS is required by default for Angular itself.
 */
import 'zone.js/dist/zone';  // Included with Angular CLI.


/***************************************************************************************************
 * APPLICATION IMPORTS
 */

(window as any)['global'] = window;

试试这个设置，让我知道。
也看看你的app.module.ts-你进口Dragula的方式好吗？

@NgModule({
    declarations: [
        ...
    ],
    imports: [
        ...
        DragulaModule.forRoot(),
        ...
    ],
    exports: [
        ...
    ],
    providers: [
       ...    ],
    bootstrap: [AppComponent]
})

请注意，这应该是应用的主app.module.ts，而不是任何子模块或延迟加载模块。

也可以通过添加以下内容来解决

(window as any).global = window;

到你的polyfills.ts。
参考：https://github.com/angular/angular-cli/issues/9827#issuecomment-386154063

在我看来，最好的解决方案是将此代码添加到index.html中进行测试

<script>
  if (global === undefined) {
    var global = window;
  }
</script>

这段代码是为生产而构建的（首先安装Domino ......并安装NPM）

const domino = require('domino');
const fs = require('fs');
const path = require('path');
const template = fs
  .readFileSync(path.join('dist/browser', 'index.html'))
  .toString();
const window = domino.createWindow(template);

// Ignite UI browser objects abstractions
(global as any).window = window;
(global as any).document = window.document;
(global as any).Event = window.Event;
(global as any).KeyboardEvent = window.KeyboardEvent;
(global as any).MouseEvent = window.MouseEvent;
(global as any).FocusEvent = window.FocusEvent;
(global as any).PointerEvent = window.PointerEvent;
(global as any).HTMLElement = window.HTMLElement;
(global as any).HTMLElement.prototype.getBoundingClientRect = () => {
    return {
      left: '',
      right: '',
      top: '',
      bottom: ''
  };
};

// If using IgxIconService to register icons
(global as any).XMLHttpRequest = require('xmlhttprequest').XMLHttpRequest;

// Other optional depending on your application configuration
(global as any).object = window.object;
(global as any).navigator = window.navigator;
(global as any).localStorage = window.localStorage;
(global as any).DOMTokenList = window.DOMTokenList;

您是否为浏览器定制了webpack配置？在angular.json中最有可能声明如下：

...
"build": {
  "builder": "@angular-builders/custom-webpack:browser",
  "options": {
    "customWebpackConfig": {
    "path": "./webpack.browser.config.js"
  },
  ...

那么webpack.browser.config.js可能看起来像这样：

const dotenv = require("dotenv-webpack");
const webpackConfig = {
  node: { global: true, fs: "empty" }, // Fix: "Uncaught ReferenceError: global is not defined", and "Can't resolve 'fs'".
  output: {
    libraryTarget: "umd", // Fix: "Uncaught ReferenceError: exports is not defined".
  },
  plugins: [new dotenv()],
  target: "node",
};

module.exports = webpackConfig; // Export all custom Webpack configs.

从其配置中删除target: "node"-它解决了问题。

我还得到了“global not defined”错误。我所要做的就是添加

<script>
  global = globalThis // fix for "global not defined" error
</script>

到\src\index.html（angular的主HTML文件）。但它是不同的包，我在浏览器控制台中得到了错误，所以这可能没有帮助。

我得到了同样的问题在我的一个角项目，我尝试了一些事情。最后我能够解决这个问题。我们只需要添加一行代码index.html文件。检查下面的代码。

<!-- your index.html -->
<script>

var global = global || window
</script>