您可以使列成为一个灵活容器，然后对齐复选框组以结束。我还在组中添加了一点底部边距。根据您的喜好调整。
请注意，我还调整了列类，以获得更好的移动的表示。
查看完整的页面演示，看看它的行动。

<link rel="stylesheet" href="https://cdn.jsdelivr.net/npm/bootstrap@5.2.3/dist/css/bootstrap.min.css" integrity="sha384-rbsA2VBKQhggwzxH7pPCaAqO46MgnOM80zW1RWuH61DGLwZJEdK2Kadq2F9CUG65" crossorigin="anonymous">

<form class="row g-3">
  <div class="col-md-6">
    <label for="inputEmail4" class="form-label">Email</label>
    <input type="email" class="form-control" id="inputEmail4">
  </div>
  
  <div class="col-md-6">
    <label for="inputPassword4" class="form-label">Password</label>
    <input type="password" class="form-control" id="inputPassword4">
  </div>
  
  <div class="col-6">
    <label for="inputAddress" class="form-label">Address</label>
    <input type="text" class="form-control" id="inputAddress" placeholder="1234 Main St">
  </div>
  
  <div class="col-12">
    <label for="inputAddress2" class="form-label">Address 2</label>
    <input type="text" class="form-control" id="inputAddress2" placeholder="Apartment, studio, or floor">
  </div>
  
  <div class="col-md-6">
    <label for="inputCity" class="form-label">City</label>
    <input type="text" class="form-control" id="inputCity">
  </div>
  
  <div class="col-md-4">
    <label for="inputState" class="form-label">State</label>
    <select id="inputState" class="form-select">
      <option selected>Choose...</option>
      <option>...</option>
    </select>
  </div>

  <div class="col col-md-2 d-flex flex-column justify-content-end">
    <div class="form-check mb-2">
      <input class="form-check-input" type="checkbox" id="gridCheck">
      <label class="form-check-label" for="gridCheck">
        Check me out
      </label>
    </div>
  </div>
  
  <div class="col-12">
    <button type="submit" class="btn btn-primary">Sign in</button>
  </div>
</form>

我不太确定我是否理解正确，但也许这就是你想要的？地址输入字段现在与用户/传递输入字段同时从内联更改为块。
https://jsfiddle.net/officernickwilde/fak53y2r/

<style>
.expanding-form-entry {
  min-width: 385px;
  flex-grow:1;
}</style>
<form class="row g-3">
  <div class="col-md-6">
    <label for="inputEmail4" class="form-label">Email</label>
    <input type="email" class="form-control" id="inputEmail4">
  </div>
  <div class="col-md-6">
    <label for="inputPassword4" class="form-label">Password</label>
    <input type="password" class="form-control" id="inputPassword4">
  </div>
  <div class="col-6 expanding-form-entry">
    <label for="inputAddress" class="form-label">Address</label>
    <input type="text" class="form-control" id="inputAddress" placeholder="1234 Main St">
  </div>
  <div class="col-6 expanding-form-entry">
    <label for="inputAddress2" class="form-label">Address 2</label>
    <input type="text" class="form-control" id="inputAddress2" placeholder="Apartment, studio, or floor">
  </div>
  <div class="col-md-6">
    <label for="inputCity" class="form-label">City</label>
    <input type="text" class="form-control" id="inputCity">
  </div>
  <div class="col-md-4">
    <label for="inputState" class="form-label">State</label>
    <select id="inputState" class="form-select">
      <option selected>Choose...</option>
      <option>...</option>
    </select>
  </div>
  <div class="col-md-2">
    <label for="inputZip" class="form-label">Zip</label>
    <input type="text" class="form-control" id="inputZip">
  </div>
  <div class="col-12">
    <div class="form-check">
      <input class="form-check-input" type="checkbox" id="gridCheck">
      <label class="form-check-label" for="gridCheck">
        Check me out
      </label>
    </div>
  </div>
  <div class="col-12">
    <button type="submit" class="btn btn-primary">Sign in</button>
  </div>
</form>