从DataStax的Python驱动程序v3.27开始，Cluster的contact_points参数似乎接受IP和端口的元组。
https://github.com/datastax/python-driver/blob/3.27.0/cassandra/cluster.py#L581-L585

class Cluster(object):
    ...

    contact_points = ['127.0.0.1']
    """
    The list of contact points to try connecting for cluster discovery. A
    contact point can be a string (ip or hostname), a tuple (ip/hostname, port) or a
    :class:`.connection.EndPoint` instance.

你能做到

cluster = Cluster(
    contact_points=[
      ('0.0.0.0', 9042),
      ('0.0.0.0', 9043),
    ]
    ...
)

然后将port=参数保留为空。