尝试将UseCompatibleTextRendering属性设置为true。

如果你自己绘制文本，你可以完全删除填充。下面是一个简单的自定义标签控件（RightAlignment属性更改文本对齐方式）

public partial class NoPaddingLabel : Label
{
    private TextFormatFlags flags = TextFormatFlags.SingleLine | TextFormatFlags.VerticalCenter | TextFormatFlags.Left | TextFormatFlags.NoPadding;

    public bool RightAlignment
    {
        get
        {
            return (flags & TextFormatFlags.Right) == TextFormatFlags.Right;
        }
        set
        {
            if (value)
            {
                flags = flags |= TextFormatFlags.Right;
            }
            else
            {
                flags = flags &= ~TextFormatFlags.Right;
            }
            Invalidate();
        }
    }

    public NoPaddingLabel()
    {
        InitializeComponent();
    }

    protected override void OnPaint(PaintEventArgs e)
    {
        TextRenderer.DrawText(e.Graphics, this.Text, this.Font, ClientRectangle, this.ForeColor, Color.Transparent, flags);
    }
}

我使用Canvas布局来解决这个问题：

<Canvas>
   <Label Canvas.Left="35" Canvas.Top="0" Content="Latitude:" HorizontalAlignment="Right" Foreground="red"/>
   <Label Canvas.Left="90" Canvas.Top="0" Content="nn.nnnnnn" Foreground="red" />
   <Label Canvas.Left="25" Canvas.Top="12"  Content="Longitude:" HorizontalAlignment="Right" Foreground="red"/>
   <Label Canvas.Left="90" Canvas.Top="12"  Content="nn.nnnnnn" Foreground="red" />
   <Label Canvas.Left="40" Canvas.Top="26"  Content="Date" HorizontalAlignment="Center" Foreground="Blue"/>
   <Label Canvas.Left="100" Canvas.Top="26"  Content="Time" HorizontalAlignment="Center" Foreground="Blue"/>
</Canvas>